Abcam, ab220491, Anti-SAP30L antibody - C-terminal

Size: 100µL
Rabbit Polyclonal SAP30L antibody. C-terminal. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SAP30L aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SAP30L aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9HAJ7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SAP30L also known as Sin3A associated protein 30-like is a protein weighing approximately 56 kDa. It functions as a transcriptional co-repressor meaning it helps regulate gene expression by silencing target genes. SAP30L achieves this by interacting with histone deacetylase complexes which modify chromatin structure to suppress transcription. This protein is ubiquitously expressed found in various tissues throughout the body indicating its broad role in maintaining cellular functions.
Biological function summary
SAP30L participates in chromatin remodeling through its role in the Sin3A-HDAC complex. The complex is essential for gene silencing and impacts various cellular processes including cell cycle regulation and differentiation. SAP30L's interaction with other complex members helps mediate the deacetylation of histones which keeps DNA in a condensed transcriptionally silent state. This contributes to the control of gene expression and plays a significant role in maintaining genomic stability.
Pathways
SAP30L is involved in the regulation of transcriptional pathways. It's critical in the pathway leading to cell cycle control participating alongside key proteins like HDAC1 and HDAC2. The presence of SAP30L in the Sin3A-HDAC complex allows for effective regulation of gene silencing and transcriptional repression across various genes involved in the cell cycle. This makes it vital to processes like cell growth and division.
SAP30L has implications in cancer and neurological disorders through its role in transcriptional repression. Altered function or expression of SAP30L can lead to disruptions in the regulation of gene expression contributing to oncogenesis. Dysregulation of associated proteins such as HDAC1 and HDAC2 in cancers links back to the malfunctioning pathways involving SAP30L. Its role in chromatin remodeling also suggests potential connections to neurological disorders where epigenetic regulation is disturbed impacting normal brain function.