Abcam, ab220622, Anti-LLPH antibody

Size: 100µL
Rabbit Polyclonal LLPH antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LLPH aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LLPH aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9BRT6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LLPH also known as L-Lactate Dehydrogenase A-like Protein plays a significant role in cellular metabolism by facilitating the conversion of lactate to pyruvate and back which is important for anaerobic and aerobic energy production. LLPH is approximately 42 kDa in mass. Expression of LLPH occurs in a variety of tissues including the brain liver and heart suggesting its involvement in numerous physiological processes.
Biological function summary
LLPH influences energy metabolism and cell proliferation by modulating the balance between lactate and pyruvate. LLPH functions independently and doesn't form part of any larger protein complex. Its role ensures efficient energy use within the cell making it vital for maintaining cellular homeostasis under varying oxygen conditions.
Pathways
LLPH contributes significantly to glycolysis and gluconeogenesis aiding the cellular response to changes in energy demand. It interrelates with enzymes such as pyruvate dehydrogenase which further integrate these pathways into central energy metabolism maintaining the cell’s energy equilibrium under different environmental and physiological conditions.
Changes in LLPH expression levels and activity have connections to cancer and metabolic disorders. In cancer aberrant LLPH expression often correlates with increased tumor growth and survival. It associates with oncogenes like Myc which influence cancer cell metabolism by regulating the expression of metabolic enzymes including LLPH.