Abcam, ab220639, Anti-TSR1 antibody

Size: 100µL
Rabbit Polyclonal TSR1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TSR1 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TSR1 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q2NL82

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TSR1 also known as 'ribosome biogenesis protein TSR1' is involved in pre-rRNA processing and stands significant in the maturation of the 40S ribosomal subunits. This protein has a mass of approximately 99 kDa and expresses itself in the nucleolus of cells contributing to the ribosome biogenesis pathway. TSR1 assists in converting the 90S precursor into pre-40S particles which later become functional 40S ribosomal subunits.
Biological function summary
The TSR1 protein plays a part in the formation of ribosomal subunits essential for protein synthesis within eukaryotic cells. This protein actively participates in a multiprotein complex called the small subunit (SSU) processome critical for pre-rRNA processing. TSR1 ensures proper assembly and stability of the small ribosomal subunit by interacting with other ribosome biogenesis factors ensuring efficient translation processes.
Pathways
TSR1 operates closely in the ribosome biogenesis pathway and the rRNA processing pathway. It forms associations with ribosomal proteins like RPS19 and proteins such as NOP14. These associations facilitate the maturation and processing of pre-rRNA linking TSR1's role directly to the production of essential components of the translational machinery vital for cellular function and growth.
Defects or mutations in TSR1 may associate with abnormally formed ribosomal subunits contributing to conditions such as Diamond-Blackfan anemia or other ribosomopathies. The connection between TSR1 and the ribosomal protein RPS19 suggests a potential impact on disorders marked by ineffective hematopoiesis. Understanding TSR1's interactions and pathways can provide insights into treating or managing ribosome-linked disorders.