Abcam, ab220740, Anti-ACD antibody

Size: 100µL
Rabbit Polyclonal ACD antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ACD aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ACD aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q96AP0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The target ACD also known as TPP1 is a component of the shelterin complex which protects telomeres. Its molecular mass is approximately 55 kDa. ACD is expressed mainly in the nucleus of cells where it interacts with telomeric DNA. ACD plays a role in regulating telomere length and stability contributing to cellular replication and aging processes.
Biological function summary
ACD interacts with other proteins within the shelterin complex such as POT1 and TRF1. This complex is critical in protecting chromosome ends from DNA damage responses. ACD is important for maintaining telomere integrity supporting cellular proliferation. When ACD functions properly it helps prevent chromosomal instability and potential oncogenic transformations.
Pathways
ACD participates in the telomere maintenance pathway and the DNA damage response pathway. ACD closely associates with proteins like POT1 and TRF2 in these pathways. Through these interactions ACD assists in modulating telomerase activity which is essential for balancing telomere elongation and degradation.
Disruptions in ACD function have links to conditions like dyskeratosis congenita and some cancers. ACD malfunction contributes to telomere shortening leading to premature aging and increased cancer risk. It associates with proteins like TERT in these contexts where imbalances can exacerbate disease progression.