Abcam, ab220780, Anti-HEATR5B antibody

Size: 100µL
Rabbit Polyclonal HEATR5B antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human HEATR5B aa 700-850.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HEATR5B aa 700-850. The exact immunogen used to generate this antibody is proprietary information.Q9P2D3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HEATR5B also known as CG11316-PB is a protein composed of approximately 205 kDa. The HEATR5B protein consists of HEAT repeat motifs which often facilitate protein-protein interactions. This protein expresses in various human tissues including high levels in the brain and liver. The presence of HEAT repeats suggests that HEATR5B might function as a scaffold organizing multiprotein complexes for specific cellular processes due to their architectural role in assembling proteins.
Biological function summary
HEATR5B participates actively in cellular maintenance by being part of larger multiprotein assemblies. The protein interacts with other cellular proteins supporting their stability and proper functioning. Part of its biological roles likely involves regulation due to its structural conformation which can support versatile coordination of signaling or structural complexes. Current research might be exploring its specific role given its wide expression in vital organs.
Pathways
Many cellular mechanisms rely on HEATR5B due to its structural involvement in molecular signaling and transport pathways. It associates with the mTOR signaling pathway which is essential for regulating cell growth and proliferation. Through these interactions HEATR5B might interface with key components such as mTOR and Raptor serving as a conduit that connects various cellular functions to nutrient and energy sensing.
HEATR5B shows potential relevance to neurodegenerative diseases and some forms of cancer. Disturbances in its normal expression or function could relate to disrupted cellular signaling pathways observed in brain disorders such as Alzheimer's disease. Additionally its association with proteins involved in cell growth regulation suggests a possible link to cancerous processes. Further investigation is essential to verify the direct connections and interactions including how it interacts with associated proteins such as Beta-amyloid in these disorders.