Abcam, ab220869, Anti-GK5 antibody

Size: 100µL
Rabbit Polyclonal GK5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GK5 aa 250-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GK5 aa 250-400. The exact immunogen used to generate this antibody is proprietary information.Q6ZS86

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GK5 also known as glycerol kinase 5 catalyzes the phosphorylation of glycerol to produce glycerol-3-phosphate. This enzyme mass is approximately 61 kDa. GK5 is expressed in various tissues with significant levels detected in the adipose tissue. It shares functional similarities with other members of the glycerol kinase family which play an important role in lipid and carbohydrate metabolism.
Biological function summary
GK5 contributes to lipid metabolism and energy homeostasis. GK5 functions as a monomer and it regulates the conversion of glycerol integrating signals from hormonal and nutritional cues to maintain metabolic balance. This regulation affects energy mobilization and storage connecting GK5 activity to broader metabolic needs of the cell.
Pathways
GK5 integrates into the glycerolipid metabolism pathway. It acts alongside related enzymes like glycerol-3-phosphate dehydrogenase which transforms glycerol-3-phosphate to dihydroxyacetone phosphate linking to glycolysis and gluconeogenesis. GK5 activity influences the balance between fat storage and breakdown which is important for meeting cellular energy demands.
GK5 has an association with metabolic disorders such as diabetes and obesity. Its function affects insulin signaling and lipid accumulation implicating it in the pathogenesis of insulin resistance and adiposity. GK5 interactions with proteins like adiponectin highlight its contributions to the complex network that governs metabolic health.