Abcam, ab220886, Anti-SHOX antibody

Size: 100µL
Rabbit Polyclonal SHOX antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SHOX aa 50-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SHOX aa 50-150. The exact immunogen used to generate this antibody is proprietary information.O15266

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Short Stature Homeobox (SHOX) gene encodes a transcription factor with a molecular mass of approximately 23 kDa. It functions by binding to DNA influencing the regulation of gene expression involved in growth and development. SHOX is located on the pseudoautosomal regions of the X and Y chromosomes. Expression of SHOX occurs mainly in tissues such as bone cartilage and other areas linked to skeletal formation. These features indicate its importance in skeletal system regulation.
Biological function summary
The role of SHOX extends to growth plate development contributing to normal skeletal structure and stature. SHOX influences chondrocyte function and maturation playing a role in bone growth and ossification. It acts within a complex regulatory network interacting with other growth-related proteins to modulate skeletal development during early stages of life. SHOX's presence in these networks highlights its role in foundational growth processes.
Pathways
SHOX is significantly involved in the growth plate signaling and homeostasis pathways. Its activity interconnects with other proteins such as SOX9 and RUNX2 ensuring proper proliferation and differentiation of chondrocytes. The synchrony of SHOX with these key proteins maintains growth balance and skeletal integrity highlighting its participation in the development and maintenance of the growth plate pathway.
Mutations or deletions affecting SHOX result in conditions such as Leri-Weill dyschondrosteosis and idiopathic short stature. These disorders often present with skeletal deformities and reduced stature directly linked to SHOX's role in growth regulation. Interaction between SHOX and other implicated proteins like FGFR3 is evident in these conditions as both factors contribute to the physiological pathways that regulate bone growth and skeletal integrity.