Abcam, ab220989, Anti-AXUD1 antibody

Size: 100µL
Rabbit Polyclonal AXUD1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CSRNP1 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CSRNP1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q96S65

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AXUD1 also known as C1orf61 is a protein with a molecular mass of approximately 33 kDa. It plays a role in transcription regulation by acting as a transcription factor. AXUD1 gets expressed in various tissues including notable expression in the brain and certain cancer tissues. It controls gene expression by binding to DNA sequences therefore impacting cell behavior and phenotype.
Biological function summary
AXUD1 participates in cellular responses that involve gene expression changes. It is not reported to form part of any multi-protein complex but interacts with other proteins to exert its function. In the nervous system it contributes to neurite outgrowth which is important for neuron development and function. In cancer cells AXUD1 influences processes that regulate cell proliferation migration and differentiation.
Pathways
The action of AXUD1 links to the Wnt signaling pathway and the sonic hedgehog pathway. The protein supports the regulation of gene expression downstream of these pathways influencing cellular growth and differentiation. Within these pathways AXUD1 interacts with beta-catenin in Wnt signaling facilitating transcriptional activation of target genes. The role in the sonic hedgehog pathway remains less defined but suggests involvement in cell fate determination.
AXUD1 has connections to cancer and neurological disorders. Altered expression levels of AXUD1 appear in several cancer types including glioblastoma and breast cancer suggesting its role in tumor progression. AXUD1 influences cancer by interacting with proteins like p53 a well-known tumor suppressor. Additionally in neurological disorders disruptions in AXUD1 expression or function may contribute to conditions like neurodegenerative diseases affecting proteins involved in neuronal survival and repair.