Abcam, ab221085, Anti-HEATR3 antibody

Size: 100µL
Rabbit Polyclonal HEATR3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human HEATR3 aa 300-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human HEATR3 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.Q7Z4Q2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HEATR3 also known as HEAT repeat-containing protein 3 is a protein characterized by HEAT repeats which are tandemly repeated motifs facilitating protein-protein interactions. This protein has a mass of approximately 94 kDa. Researchers have identified its expression in various tissues suggesting its broad role in cellular function. The structural design of HEATR3 implies it might act as a molecular scaffold helping in processes that need complex assemblies.
Biological function summary
HEATR3 assists in translation machinery modulation. It forms part of the R2TP/Prefoldin-like complex a multi-protein complex engaged in the assembly and maturation of large protein complexes. This involvement implies an important role in maintaining the stability and function of essential cellular structures. Additionally HEATR3 interacts with proteins containing HEAT repeats hinting at remarkable versatility in cellular tasks.
Pathways
HEATR3 is important in the process of ribosome biogenesis and cellular stress response pathways. It works closely with the PI3K/AKT signaling pathway aiding in the regulation of growth and survival signals. The interaction with related pathway proteins such as PIH1D1 indicates HEATR3's participation in cellular systems affecting proliferation and apoptosis.
HEATR3 expression and function appear linked to cancer and neurodegenerative diseases. Abnormal expression patterns or mutations in HEATR3 might contribute to the pathogenesis of specific cancer types potentially through disrupted interactions with MTOR or other cancer-related proteins. Additionally the protein's role in proper cellular assembly and stress response implicates it in neurodegenerative disorders where these processes are often impaired.