Abcam, ab221123, Anti-UCP5 antibody

Size: 100µL
Rabbit Polyclonal UCP5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A14 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC25A14 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O95258

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Uncoupling protein 5 (UCP5) also known as BMCP1 is a member of the mitochondrial carrier family which plays a role in regulating energy balance and thermogenesis. The protein has a molecular weight of approximately 34 kDa. UCP5 is primarily expressed in the brain and testicular tissues with its highest levels found in the hypothalamus. This protein is homologous to UCP1 UCP2 and UCP3 which are known for their involvement in mitochondrial uncoupling processes.
Biological function summary
UCP5 participates in the dissipation of the proton gradient across the inner mitochondrial membrane which leads to the generation of heat instead of ATP. It acts independently and is not typically part of a multi-protein complex in its functions. By facilitating proton leaks UCP5 contributes to the regulation of oxidative stress preventing excessive reactive oxygen species (ROS) formation. This function suggests roles in metabolic adaptation especially under conditions where thermogenesis is required such as cold exposure.
Pathways
UCP5 is primarily involved in the mitochondrial electron transport chain and energy metabolism pathways. It modulates the coupling efficiency of oxidative phosphorylation. The protein can interact with UCP1 in thermogenic energy regulation although UCP1 is predominantly found in brown adipose tissue. Its activity might influence adaptive thermogenesis pathways potentially intersecting with signaling pathways regulated by leptin which is a hormone associated with energy expenditure control.
UCP5 has been linked to conditions such as obesity and neurodegenerative disorders. In obesity the protein might affect energy balance and metabolic efficiency potentially interacting with leptin. Neurodegenerative disorders like Alzheimer’s disease see a connection through the regulation of mitochondrial reactive oxygen species where UCP5 can mitigate oxidative damage. Such disorders often involve oxidative stress and proteins like UCP2 may operate in a similar capacity in neural tissues to help protect against cellular damage.