Abcam, ab221137, Anti-C9orf72 antibody [EPR22021]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal C9orf72 antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR22021,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C9orf72 also known as Chromosome 9 Open Reading Frame 72 is a protein with a molecular mass of approximately 54 kDa. This protein is abundantly expressed in the brain particularly in neurons and is also present in other tissues including muscle and blood. Mechanically C9orf72 is involved in nucleocytoplasmic transport and plays a role in autophagy a process important for cell maintenance by degrading and recycling cellular components.
Biological function summary
C9orf72 supports normal cellular homeostasis through its role in autophagy and lysosomal function. It forms part of a protein complex with WDR41 and SMCR8 contributing to the regulation of the small GTPases of the Rab family. C9orf72 affects trafficking and degradation of vesicles processes important for neuronal health and function.
Pathways
C9orf72 interacts with several cellular mechanisms involved in the regulation of autophagy and endosomal trafficking. It is an important player in the mTOR signaling pathway which is significant for cell growth proliferation and survival. C9orf72 also associates with the ULK1 complex connecting it to the early steps of autophagy induction. These interactions suggest that C9orf72 may influence various cellular processes through its regulatory functions.
Alterations in C9orf72 are closely associated with neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Mutations or expansions in the C9orf72 gene contribute to these conditions by disrupting normal protein function leading to neuronal damage and degeneration. The protein is connected to TDP-43 which deposits abnormally in tissues of ALS and FTD patients linking it to the pathophysiology of these disorders.