Abcam, ab221447, Anti-CEP164 antibody

Size: 100µL
Rabbit Polyclonal CEP164 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CEP164 aa 350-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CEP164 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q9UPV0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CEP164 protein also known as Centrosomal Protein of 164 kDa serves key functions in cells. It has a mass around 164 kilodaltons and localizes in the centrioles of the cells. CEP164 strongly expresses in tissues with high cell division activity such as testes and the cerebellum. This protein is vital for the maturation and stability of centrosomes which organize microtubules and facilitate proper cell division.
Biological function summary
CEP164 interacts with several important protein complexes within the cell. It plays a critical role in initiating ciliogenesis by recruiting proteins necessary for cilia formation like Tau tubulin kinase 2 (TTBK2) and others. Cilia are hair-like structures extending from the cell surface that are important for cell movement and signaling. CEP164 also assists in DNA damage response by aiding in the localization of DNA repair proteins to damaged sites securing genomic stability.
Pathways
The integration of CEP164 in cellular pathways is important. It participates significantly in the DNA damage response pathway and is closely associated with DNA damage checkpoint proteins like ATM and ATR. Additionally it acts in the cilia assembly pathway coordinating with proteins like TTBK2 and RPGRIP1L to ensure proper ciliary function and signaling. These interactions contribute to cellular decisions on DNA repair and signaling mechanisms.
Abnormalities in CEP164 associate with several conditions. Mutations in the CEP164 gene can contribute to diseases like nephronophthisis a rare kidney disorder and Senior-Løken syndrome which involves kidney and retinal degeneration. In nephronophthisis CEP164's interaction with TTBK2 and other ciliary proteins becomes impaired leading to dysfunctional cilia and disrupted cell signaling.