Abcam, ab221453, Anti-APMAP antibody

Size: 100µL
Rabbit Polyclonal APMAP antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human APMAP aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human APMAP aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q9HDC9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
APMAP also known as adipocyte plasma membrane-associated protein is an integral membrane protein that weighs approximately 45 kDa. APMAP localizes primarily in adipose tissues and hepatocytes. This protein resides within both the plasma membrane and intracellular compartments. APMAP participates in lipid metabolism through its interactions with various protein complexes. Its expression levels vary across different tissues reflecting a specialized role in certain physiological functions.
Biological function summary
APMAP functions within the modulation of lipid homeostasis especially in adipocytes. It shows involvement in triglyceride metabolism by regulating enzyme activity responsible for lipid turnover. APMAP acts as a part of a protein complex that includes enzymes affecting lipid storage and release. Through such interactions APMAP influences key biological processes that maintain lipid balance supporting energy homeostasis in mammals.
Pathways
APMAP integrates into the lipid metabolic pathway particularly those impacting triglyceride storage and hydrolysis. APMAP associates with proteins like perilipin which also participate in lipid droplet formation and breakdown. Additionally APMAP's involvement with AMP-activated protein kinase (AMPK) signaling influences cellular energy status linking it to pathways controlling metabolism and energy sensing.
APMAP shows association with metabolic syndrome and type 2 diabetes. Its role in lipid metabolism connects APMAP to insulin signaling pathways where altered expression or function may contribute to these metabolic disorders. APMAP's relationship with adiponectin a protein with anti-diabetic properties indicates its potential impact on glucose metabolism dysregulation. Understanding APMAP's function helps unravel molecular underpinnings of metabolic diseases offering insights for targeted therapeutic approaches.