Abcam, ab221487, Anti-MYPOP antibody

Size: 100µL
Rabbit Polyclonal MYPOP antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYPOP aa 100-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYPOP aa 100-250. The exact immunogen used to generate this antibody is proprietary information.Q86VE0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MYPOP also known as Myb-related transcription factor is a DNA-binding protein involved in transcriptional regulation. It has a molecular mass of approximately 68 kDa. This protein localizes mainly in the nucleus where it binds DNA to influence gene expression. MYPOP is expressed in various human tissues most notably in the immune and hematopoietic systems indicating its importance in immune regulation.
Biological function summary
MYPOP acts as a transcription factor influencing cell proliferation and differentiation. It does not function alone but forms part of larger transcriptional complexes. By interacting with other transcriptional regulators it modulates the expression of genes necessary for cell cycle progression and hematopoietic processes. MYPOP holds a significant role in the maintenance of normal cellular functions and the immune response.
Pathways
MYPOP participates in essential transcriptional and immune signaling pathways. It is involved in the regulation of the p53 signaling pathway which is known for its role in controlling cell cycle and apoptosis. MYPOP shows interactions with related proteins such as Myb and p53 coordinating transcriptional responses critical for DNA damage repair and maintaining genomic integrity.
MYPOP links to conditions such as leukemia and lymphoma. Its dysregulation affects cellular proliferation and survival contributing to hematological malignancies. Proteins like Myb which also influence transcription show a connection to MYPOP in these disorders as they cooperate in pathways that when altered lead to abnormal cell growth and cancer development. Understanding MYPOP's role could help in developing targeted therapies for these diseases.