Abcam, ab221559, Anti-MAGEB2 antibody

Size: 100µL
Rabbit Polyclonal MAGEB2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MAGEB2 aa 150-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MAGEB2 aa 150-200. The exact immunogen used to generate this antibody is proprietary information.O15479

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MAGEB2 or Melanoma Antigen Family B2 is part of the MAGEB family of proteins. It is a protein of about 32 kDa often known for its role in immunity and cancer biology. MAGEB2 expresses mainly in brain tissue and some cancers. Its presence in cancer types like melanoma makes it a significant subject for studies exploring tumor antigens and potential therapeutic targets.
Biological function summary
This protein involves itself in complex molecular interactions. MAGEB2 does not function alone; it associates with other proteins to regulate cellular processes such as apoptosis and cell cycle control. Its expression in specific tissues suggests roles in tissue-specific functions that are still the subject of research.
Pathways
Studies show MAGEB2 interacting within the p53 signaling pathway. It also connects with proteins like p53 and p73 which are well-known for their roles in these pathways. Through such interactions MAGEB2 can participate in cellular stress responses influencing the survival or death of cells undergoing stress.
Researchers link MAGEB2 to cancer especially melanoma and lung cancer. MAGEB2 serves as a tumor-associated antigen that can initiate immune responses against cancer cells. It shows connections to the MAGEA family proteins which also associate with cancer providing potential biomarkers for diagnosis or targets for immunotherapy.