Abcam, ab221615, Anti-IPO11 antibody

Size: 100µL
Rabbit Polyclonal IPO11 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human IPO11 aa 800-950.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IPO11 aa 800-950. The exact immunogen used to generate this antibody is proprietary information.Q9UI26

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IPO11 also known as Importin-11 is a protein involved in nuclear transport. It weighs approximately 112 kDa and is expressed in multiple tissues including the brain lung and liver. It functions mechanically by interacting with nuclear localization signals on target proteins facilitating their transport across the nuclear envelope through the nuclear pore complex. This transport is dependent on the Ran GTPase cycle which provides directional movement by altering affinity for cargo proteins.
Biological function summary
IPO11 plays a role in the regulation of protein localization and gene expression. It is part of various nuclear transport complexes functioning to import key regulatory proteins like transcription factors and enzymes into the nucleus. This role supports cell cycle progression and cellular responses to external stimuli by ensuring that necessary proteins reach the nucleus for specific gene regulation activities.
Pathways
IPO11 is involved in the nuclear import pathway and the Ran GTPase cycle. These pathways are essential for the selective transport of proteins and RNAs between the nucleus and cytoplasm. IPO11 works closely with proteins like Ran and other importins to execute these processes. It ensures the transport is timely and consistently provided for the correct nuclear protein composition.
IPO11 has been associated with cancer and neurodegenerative diseases. Aberrant function or expression levels of IPO11 may lead to mislocalization of tumor suppressor proteins or oncogenes contributing to tumorigenesis. It also interacts with proteins involved in neurodegenerative pathways such as tau in Alzheimer's disease affecting its transport and function within neurons. This connection indicates potential involvement of IPO11 in disease progression and pathology.