Abcam, ab221652, Anti-Ephrin B1 antibody

Size: 100µL
Rabbit Polyclonal Ephrin B1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EFNB1 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human EFNB1 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.P98172

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ephrin-B1 also known as B1 protein or Ephrin-B1 protein is a member of the ephrin family with a mass around 25 kDa. Located on the plasma membrane Ephrin-B1 mainly expresses in the nervous system skeletal system and some epithelial tissues. The protein functions as a ligand for the Eph receptor family which plays a role in cell signaling. Ephrin-B1 interacts with Eph receptors through bi-directional signaling influencing cellular communication and movement.
Biological function summary
Ephrin-B1 is critical for cell positioning and boundary formation. It is part of a transmembrane protein complex influencing cell-to-cell interactions. Through its role in adhesion and repulsion Ephrin-B1 helps coordinate developmental processes such as tissue assembly and organ development. The protein serves essential roles in maintaining cellular architecture ensuring that cells adhere and detach properly during development and wound repair.
Pathways
The ephrin-B1 signaling is important to the Eph receptor pathways particularly the EphB forward and reverse signaling pathways. These pathways are well known for their functions in axon guidance and synaptic plasticity linking Ephrin-B1 with the nervous system development. Related proteins in these pathways include EphB2 and EphB4 which work alongside Ephrin-B1 in regulating the dynamics of these pathways facilitating processes like neurite outgrowth and spine morphogenesis.
Ephrin-B1 is associated with cleft palate and craniofrontonasal syndrome. Mutations or dysregulation in Ephrin-B1 can disrupt normal tissue boundary formation and cell migration leading to such developmental disorders. Abnormal interaction between Ephrin-B1 and related proteins such as EphB2 can affect developmental signaling cascades highlighting the importance of this protein in proper craniofacial and tissue development.