Abcam, ab221661, Anti-Mitofusin 1 antibody [EPR21953-74]

Size: 20µL / 100µL / 1mL
Anti-Mitofusin 1 antibody [EPR21953-74] (ab221661) is a rabbit monoclonal antibody detecting Mitofusin 1 in Western Blot, IP . Suitable for Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency - Over 10 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR21953-74,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
What is this antibody validated in?
Anti-Mitofusin 1 antibody [EPR21953-74] (ab221661) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunoprecipitation (IP) in Mouse, Rat samples.
What is the molecular weight of Mitofusin 1?
Anti-Mitofusin 1 [EPR21953-74] (ab221661) specifically detects a band for Mitofusin 1 (UniProt: Q811U4) at a molecular weight of 84kDa.
Trusted by the scientific community
Anti-Mitofusin 1 [EPR21953-74] (ab221661) was first used in a scientific publication in 2019 and has been cited over 10 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [EPR21953-74] also available for your convenience: ab221661, Carrier free -
ab254198
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Mitofusin 1 (MFN1) also known as mfn1 is a GTPase protein involved in mitochondrial fusion with a molecular weight of approximately 84 kDa. This protein is expressed in various tissues most notably in skeletal muscle cardiac muscle and the nervous system. Mitofusin 1 plays a significant role in maintaining mitochondrial structure and function by facilitating the fusion of outer mitochondrial membranes which is essential for normal mitochondrial dynamics.
Biological function summary
Mitofusin 1 is involved in processes beyond just mitochondrial fusion. It participates in mitochondrial quality control and bioenergetics helping to optimize the distribution of mitochondrial DNA and components across the mitochondrial network. Mitofusin 1 is also part of a complex that involves Mitofusin 2 (MFN2). Together these proteins regulate interactions between mitochondria and other organelles contributing to cellular homeostasis and adaptation to metabolic demands.
Pathways
Mitofusin 1 plays a role in the mitochondrial fusion and fission pathway which is critical for mitochondrial and cellular health. It interacts closely with other proteins like OPA1 (optic atrophy 1) an important regulator in the fusion process. Moreover Mitofusin 1 is integrated into the apoptosis pathway where it influences cell survival and death. Its interaction with Bak and Bax proteins which are involved in apoptotic signaling highlights the role of Mitofusin 1 in balancing cell fate decisions.
Mutations or dysregulation of Mitofusin 1 have associations with neurodegenerative diseases and cardiomyopathies. For instance defects in Mitofusin 1 are linked to Charcot-Marie-Tooth disease type 2A a disorder affecting peripheral nerves. Additionally disturbances in Mitofusin 1 function have implications for heart health particularly in relation to heart failure where proper mitochondrial dynamics are disrupted. Through these conditions Mitofusin 1 also interacts with associated proteins like Mitofusin 2 reflecting shared roles in the pathology of these disorders.