Abcam, ab221725, Anti-MYSM1 antibody

Size: 100µL
Rabbit Polyclonal MYSM1 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYSM1 aa 400-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYSM1 aa 400-550. The exact immunogen used to generate this antibody is proprietary information.Q5VVJ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MYSM1 also known as Myb-like SWIRM and MPN domains 1 functions as a histone H2A deubiquitinase. This protein weighs approximately 83 kDa. MYSM1 is found in the nucleus and shows expression in various tissues including hematopoietic cells such as T cells and bone marrow. By removing ubiquitin from histone H2A MYSM1 influences chromatin structure and gene transcription.
Biological function summary
MYSM1 plays an important role in regulating gene expression during processes like hematopoiesis and immune development. It forms part of a chromatin remodeling complex that modulates transcriptional activity by altering nucleosome configuration. This function is essential for proper stem cell maintenance and differentiation by ensuring that transcriptionally active and inactive regions are appropriately maintained and accessed.
Pathways
MYSM1 participates in the ubiquitin-proteasome pathway and is involved in DNA damage response. It associates closely with proteins like TP53 where it aids in governing cell cycle progression and apoptosis. MYSM1 also interacts with histone modification machinery exerting effects on transcriptional silencing and activation particularly influencing genes associated with immune cell lineage commitment.
MYSM1 impacts conditions such as bone marrow failure and immunodeficiency. It connects with the TP53 protein where mutations or dysregulation in this pathway can lead to hematological abnormalities and impaired immune function. MYSM1 deficiency has been implicated in defective T cell maturation and aberrant myeloid lineage decisions contributing to these disorders.