Abcam, ab221740, Anti-TSPAN11 antibody

Size: 100µL
Rabbit Polyclonal TSPAN11 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Tetraspanin-11 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.A1L157

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TSPAN11 also known as tetraspanin-11 is a member of the tetraspanin family a group of proteins characterized by four transmembrane domains. TSPAN11 has a molecular mass of approximately 24 kDa. It is expressed in various tissue types including lung kidney and immune cells. TSPAN11 proteins usually have essential roles in cellular processes through interactions with other transmembrane proteins and components of the cell membrane.
Biological function summary
TSPAN11 participates actively in cell adhesion migration and proliferation. It is part of the tetraspanin web a complex arrangement of proteins on the cell surface. Tetraspanins like TSPAN11 facilitate the organization of molecular complexes known as tetraspanin-enriched microdomains (TEMs). These microdomains help regulate intracellular signaling pathways that are important for cellular events.
Pathways
TSPAN11 influences cellular processes by engaging in the PI3K/AKT signaling pathway. It interacts with proteins such as integrins to mediate cell adhesion and migration. TSPAN11 also associates with proteins within the EGFR signaling pathway aiding in the modulation of cellular proliferation and survival. These interactions highlight TSPAN11's role in maintaining cellular function and response to external stimuli.
TSPAN11 links to certain cancers and immune-related diseases. Aberrant expression or dysfunction of TSPAN11 affects cell migration and adhesion contributing to cancer metastasis. It has connections with other proteins like integrin involved in these processes. Additionally TSPAN11 may play a role in autoimmune diseases by affecting immune cell functions interacting with proteins that regulate immune responses and inflammation.