Abcam, ab221804, Anti-OATP1A2 antibody

Size: 100µL
Rabbit Polyclonal OATP1A2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 7 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLCO1A2 aa 250-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLCO1A2 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.P46721

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
OATP1A2 also known as Organic Anion Transporting Polypeptide 1A2 or SLC21A3 functions as a solute carrier responsible for the transport of various endogenous and exogenous organic anions. This protein plays an important role in drug absorption distribution and clearance. OATP1A2 has a molecular weight of approximately 76 kDa. It is mainly expressed in the liver but you can also find it in the small intestine brain and kidney. Its expression in multiple tissues highlights its significant role in pharmacokinetics.
Biological function summary
OATP1A2 mediates the uptake of a wide range of substrates including bile acids steroid conjugates thyroid hormones and various drugs. It does not form part of a larger protein complex which means it acts independently in its transporter function. The protein facilitates the entry of compounds critical for cellular metabolism and detoxification making it an important player in maintaining cellular homeostasis.
Pathways
This transporter integrates into essential biological processes particularly the hepatic and intestinal transport pathways. In the liver it works in conjunction with other transporters like NTCP and BCRP to manage bile secretion and drug clearance. Moreover it participates in the regulation of drug bioavailability and efficacy often interacting with the P-glycoprotein pathway in the small intestine.
OATP1A2 demonstrates an important role in conditions such as cancer and drug-induced toxicity. Alterations in its function or expression can influence cancer development due to impaired drug transport and disposition. Additionally improper functioning of OATP1A2 has been linked to an increased risk of adverse drug reactions particularly in combination with other transporters like NTCP which also share substrates. Understanding these connections helps in managing and predicting treatment outcomes.