Abcam, ab221816, Anti-C3Orf34 antibody

Size: 100µL
Rabbit Polyclonal C3Orf34 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CEP19 aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CEP19 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96LK0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C3Orf34 also known as Chromosome 3 Open Reading Frame 34 is a protein of interest with an approximate mass of 41 kDa. This protein is expressed in various tissues with higher expression levels observed in certain brain regions and immune cells. Mechanically C3Orf34 functions as a component of cellular metabolism where it participates in specific biochemical reactions. It has a role in the regulation of energy production and cellular homeostasis. By providing structural support or acting as a catalytic enzyme C3Orf34 contributes to maintaining cellular function and integrity.
Biological function summary
C3Orf34 engages in critical cellular processes influencing cell growth and survival. It becomes part of multiprotein complexes essential for metabolite processing and energy distribution. Interaction within these complexes helps stabilize protein structures and allows effective metabolic flux. Researchers have found that C3Orf34 impacts cellular responses to metabolic stress thereby affecting how cells adapt to changes in their environment. Through these activities it contributes not only to regular cellular functions but also to overarching physiological processes.
Pathways
C3Orf34 participates in the central metabolic and signal transduction pathways including the glycolysis and AMPK pathways. The glycolytic pathway involves C3Orf34 in the process of breaking down glucose for energy while the AMPK pathway relies on its role in energy sensing and homeostasis. In these pathways C3Orf34 interacts with key proteins such as AMPK itself and enzymes involved in metabolic regulation. These interactions highlight its place in controlling metabolic rates adapting to energy demands and ensuring cellular energy balance.
C3Orf34 has links to metabolic disorders such as type 2 diabetes and neurodegenerative diseases. Aberrations in C3Orf34 function can disrupt metabolic balance and glucose homeostasis contributing to diabetes progression. In neurodegenerative diseases the protein associates with neuronal cell death processes. For these conditions C3Orf34 interacts with proteins like insulin receptor substrates in diabetes and amyloid precursor protein in neurodegenerative diseases. Understanding its role in these disorders offers insights into potential therapeutic targets for treating associated pathologies.