Abcam, ab222245, Anti-FOXA3 antibody

Size: 100µL
Rabbit Polyclonal FOXA3 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FOXA3 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FOXA3 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.P55318

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FOXA3 also known as Forkhead box protein A3 is a transcription factor that belongs to the FOX family. It has a molecular mass of approximately 43 kDa. FOXA3 exhibits expression mainly in the liver pancreas and lung tissues where it regulates the transcription of genes involved in metabolic processes. It has a highly conserved DNA-binding domain known as the forkhead or winged helix domain which allows binding to specific DNA sequences to control gene expression.
Biological function summary
FOXA3 plays an important role in the regulation of glucose and lipid homeostasis. It promotes the expression of genes involved in gluconeogenesis and lipogenesis processes. As a component of a transcriptional complex FOXA3 interacts with other transcription factors and co-activators to modulate target gene transcription. Its regulatory activities help maintain the balance of energy supply and storage in response to physiological needs.
Pathways
FOXA3 participates in significant metabolic pathways that are essential for energy production and storage. One important pathway involves gluconeogenesis where FOXA3 partners with other transcription factors such as HNF4α to promote the expression of genes required for glucose synthesis. Additionally FOXA3 is involved in lipid metabolism pathways coordinating with proteins like PPARG to regulate lipogenic genes ensuring proper lipid storage and utilization in cells.
FOXA3 is linked to conditions like type 2 diabetes and non-alcoholic fatty liver disease (NAFLD). Aberrant regulation of FOXA3 can disturb glucose and lipid metabolism contributing to the development of these metabolic disorders. FOXA3 interacts with proteins such as PPARG and HNF4α which also have implications in these diseases by modulating pathways that affect insulin sensitivity and fat accumulation. Proper function of FOXA3 is essential for maintaining metabolic health.