Abcam, ab222251, Anti-ELF5 antibody

Size: 100µL
Rabbit Polyclonal ELF5 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ELF5 aa 150-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ELF5 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.Q9UKW6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ELF5 also known as E74 Like ETS Transcription Factor 5 is a transcription factor with a mass of approximately 27 kDa. It belongs to the ETS family and plays a role in regulating gene expression by binding to specific DNA sequences. ELF5 localizes mainly in epithelial tissues where it influences development and differentiation. This targeting involves critical cellular processes particularly affecting mammary gland and placental development.
Biological function summary
ELF5 plays a significant role in maintaining the balance between cellular proliferation and differentiation. It operates within specific protein complexes to modulate the luminal epithelial cell fate in the mammary gland. ELF5 regulates critical genes responsible for alveolar development contributing to normal lactation. In placental tissues it affects trophoblast differentiation and normal placental function reflecting its impact on fetal development.
Pathways
ELF5 actively participates in pathways involving hormone response and epithelial cell differentiation. It interacts closely with proteins such as GATA3 within these pathways which help regulate luminal cell differentiation in the mammary gland. ELF5 also participates in the Wnt signaling pathway demonstrating its multifaceted roles by influencing cell fate decisions and maintaining epithelial homeostasis.
ELF5 shows connections to breast cancer and placental disorders. Changes in ELF5 expression can impact breast cancer progression by altering epithelial cell states emphasizing its predictive role in cancer biology. Aberrant ELF5 levels may contribute to conditions like pre-eclampsia through its association with critical proteins such as GATA3 affecting normal placental function and development.