Abcam, ab222325, Anti-K80 antibody

Size: 100µL
Rabbit Polyclonal K80 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KRT80 aa 350 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KRT80 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6KB66

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
K80 is a protein also known as Keratin 80. It plays a structure role in cells providing mechanical support particularly in epithelial cells. The protein has a mass of approximately 57 kDa and is expressed significantly in the skin hair follicles and nails. In these tissues K80 contributes to the keratin filament network that offers integrity and resilience to cells undergoing mechanical stress.
Biological function summary
K80 contributes to the formation of intermediate filaments which are part of the cellular cytoskeleton. These filaments provide structural stability and are essential for the differentiation of epithelial cells. K80 often functions as part of a larger keratin complex interacting with other keratins to maintain the strength and functionality of the structural network. It participates in the keratinization process important for forming the protective barrier of the skin.
Pathways
Research shows that K80 participates in the epidermal differentiation pathway. This pathway is responsible for the development and maintenance of the skin barrier. K80 interacts with other keratin proteins such as Keratin 5 and Keratin 14 to form heterodimers and filament complexes. These interactions ensure proper skin formation and response to mechanical pressures.
Abnormalities in K80 expression or function can relate to skin diseases like keratinopathic ichthyosis and hair disorders such as alopecia. Mutations in K80 disrupt the formation of keratin filaments leading to impaired skin integrity and hair structure. The protein's malfunctions might indirectly contribute to disorders through its interaction with other keratin proteins like Keratin 6 which also plays a role in these conditions.