Abcam, ab222383, Anti-ADAMTS7 antibody

Size: 100µL
Rabbit Polyclonal ADAMTS7 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human A disintegrin and metalloproteinase with thrombospondin motifs 7 aa 1300-1400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human A disintegrin and metalloproteinase with thrombospondin motifs 7 aa 1300-1400. The exact immunogen used to generate this antibody is proprietary information.Q9UKP4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ADAMTS7 also known as ADAM Metallopeptidase with Thrombospondin Type 1 Motif 7 is an enzyme with a molecular mass of approximately 180 kDa. This protein is part of the ADAMTS family characterized by a disintegrin and metalloproteinase with thrombospondin motifs. ADAMTS7 is expressed mainly in the human kidney liver and skeletal muscle tissues. This protein plays a significant role in the degradation and remodeling of the extracellular matrix mediating processes such as protein processing and extracellular matrix assembly.
Biological function summary
ADAMTS7 functions as an important regulatory enzyme involved in the processing of cartilage oligomeric matrix protein (COMP). This process impacts the integrity and function of cartilage suggesting its vital role in maintaining cartilage homeostasis. Though it does not form part of a larger complex ADAMTS7 interacts closely with extracellular matrix components modulating cellular processes connected to tissue organization and structural integrity.
Pathways
ADAMTS7 is integral to the extracellular matrix organization pathway impacting its degradation and synthesis. It is also associated with the focal adhesion pathway which is critical for cell adhesion migration and signal transduction. In these pathways ADAMTS7 acts alongside proteins such as integrins and other matrix metalloproteinases coordinating cellular responses to mechanical and chemical stimuli through direct protein interactions.
ADAMTS7 has a connection to atherosclerosis and osteoarthritis. In atherosclerosis ADAMTS7 influences the remodeling of vascular tissues with effects on arterial stiffness and plaque stability. It interacts with proteins like low-density lipoprotein receptor-related protein 1 (LRP1) affecting lipid accumulation and inflammatory responses. In osteoarthritis ADAMTS7 contributes to cartilage degradation linking with other matrix-degrading enzymes to influence the progression of joint degeneration and inflammation.