Abcam, ab222811, Anti-LSDP5 antibody

Size: 50µL
Rabbit Polyclonal LSDP5 antibody. Suitable for WB and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PLIN5 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q00G26

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LSDP5 also known as PLIN5 or Perilipin 5 is a protein that plays an important role in lipid droplet formation and regulation. Its molecular mass is approximately 52 kDa. This protein is mainly expressed in tissues with high lipid metabolism such as muscle and liver. LSDP5 localizes to the surface of lipid droplets where it regulates triglyceride storage and release connecting to various metabolic processes.
Biological function summary
The protein contributes to the organization of lipid droplets and regulation of lipid storage in the cell. It is not typically part of a large protein complex. By modulating lipid droplet formation LSDP5 controls the flow of fatty acids in and out of these storage organelles. This action influences energy balance in cells and aids adaptation to metabolic changes supporting both lipid storage and mobilization as needed.
Pathways
The protein influences energy homeostasis and lipid metabolism pathways notably the peroxisome proliferator-activated receptor (PPAR) pathway. It works in association with other lipid-related proteins including perilipin 1 and adipose triglyceride lipase coordinating lipid storage and hydrolysis. These interactions help regulate the balance between storage and use of lipids impacting mitochondrial energy production.
LSDP5 is connected to metabolic conditions like obesity and type 2 diabetes. Aberrations in its expression or function may lead to dysregulated lipid storage contributing to these metabolic disorders. It interacts with proteins such as PGC-1α which is involved in managing mitochondrial biogenesis and energy expenditure linking it to disease states characterized by impaired energy metabolism.