Abcam, ab22285, Anti-Avian Influenza Nucleoprotein antibody

Size: 100µg
Rabbit Polyclonal NCAP antibody. Suitable for ELISA, ICC/IF and reacts with Influenza A samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Influenza A,
Applications:ICC/IF, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Avian Influenza Nucleoprotein also known as NP is a structural protein found in influenza viruses particularly avian strains. It functions mechanically as a part of the ribonucleoprotein (RNP) complex encapsulating the viral RNA in a helical structure therefore facilitating its replication and transcription. The molecular weight of the nucleoprotein is approximately 56 kDa. It expresses predominantly within the host cell's cytoplasm participating in viral assembly and eventually packaging.
Biological function summary
The nucleoprotein functions as an important player in viral replication and interaction with host cell machinery. Within the RNP complex it binds to viral RNA and polymerase subunits ensuring the stability of viral genome replication. Additionally the nucleoprotein interacts with host nuclear import and export pathways to shuttle viral components across the nuclear membrane efficiently important for viral propagation within host cells.
Pathways
Avian Influenza Nucleoprotein influences viral RNA synthesis and export pathways. It associates with viral polymerase proteins such as PA PB1 and PB2 during the viral RNA replication process. Moreover its interaction with nuclear export factors like exportin-1 (CRM1) integrates it into the host's nuclear export pathway facilitating the movement of viral RNA from nucleus to cytoplasm which is essential for the completion of the viral life cycle.
Avian Influenza Nucleoprotein is central to the pathogenicity of avian influenza infections which can result in avian influenza virus (AIV) outbreaks. This relationship with AIV highlights its importance in zoonotic transmission and potential emergence of avian influenza in humans. Its association with proteins involved in the immune response such as interferon-inducible proteins also highlights its role in modulating host immune evasion a factor that complicates the control of influenza outbreaks.