Abcam, ab222895, Anti-DMRT1 antibody

Size: 50µL
Rabbit Polyclonal DMRT1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DMRT1 aa 150 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human DMRT1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y5R6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The DMRT1 protein also known as Doublesex and Mab-3 related transcription factor 1 plays a mechanical role in sex determination and differentiation. This protein with an approximate mass of 40 kDa functions primarily as a transcription factor. DMRT1 is expressed in the gonads particularly in testicular tissues where it contributes to the development and maintenance of male-specific traits. The DMRT1 gene located on chromosome 9 in humans encodes this zinc finger-like DNA binding protein.
Biological function summary
The DMRT1 protein regulates the expression of other genes that are essential for male sexual development and spermatogenesis. As part of its biological role DMRT1 is an important factor in the formation of testicular structures and ensures the survival of male germ cells. The protein functions as part of complexes that interact with other transcriptional regulators to modulate gene activity. By exerting control over male-biased gene expression DMRT1 helps maintain the balance of sex-specific pathways while suppressing genes linked to female differentiation.
Pathways
The DMRT1 protein acts as a central player in the sex determination and development pathways. It is involved in the testis differentiation pathway which includes interactions with SOX9 and other transcription factors like SF1. DMRT1 also associates with pathways influencing Sertoli cell proliferation and function which are key in sustaining spermatogenesis. The engagement of DMRT1 in these pathways highlights its interconnected role with proteins that oversee reproductive development and function.
The DMRT1 protein shows connections to sex development disorders and testicular cancers. Abnormalities in DMRT1 expression or function can result in conditions like gonadal dysgenesis due to disrupted testicular differentiation. Testicular cancer also associates with altered DMRT1 activity. In these contexts mutations in DMRT1 or interacting partners like AMH have been linked with deviations from normal testicular development or tumorigenesis illustrating important clinical relevance and potential therapeutic interest.