Abcam, ab222967, Anti-ACTR5 antibody

Size: 50µL
Rabbit Polyclonal ACTR5 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ACTR5 aa 150-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ACTR5 aa 150-300. The exact immunogen used to generate this antibody is proprietary information.Q9H9F9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACTR5 also known as ARP5 forms part of the Actin-Related Protein family. This protein plays a role in chromatin remodeling through its involvement in the INO80 complex. Its molecular mass is approximately 38 kDa. ACTR5 expresses in a broad range of tissues indicating its fundamental role in cellular functions and suggesting its importance in diverse biological processes.
Biological function summary
ACTR5 assists in nucleosome repositioning as part of the INO80 chromatin remodeling complex. This complex modifies chromatin structure facilitating access to DNA for transcription replication and repair. ACTR5 helps in regulating gene expression thereby influencing cellular response to environmental signals. Its activity reflects how cells manage genomic functions and maintain genetic integrity across development and differentiation.
Pathways
ACTR5 engages in chromatin remodeling and DNA damage response pathways. Within these pathways ACTR5 associates with proteins like INO80 and YY1 modulating transcriptional regulation. The presence of ACTR5 in the INO80 complex underlines its responsibility in genome stability and transcription representing a link between chromatin dynamics and cellular genome maintenance mechanisms.
ACTR5 alters processes involved in cancer and neurological disorders. The disruption of ACTR5 or associated proteins like INO80 and YY1 can lead to tumorigenesis through impaired genetic regulation and stability. In the nervous system malfunctioning chromatin remodeling mechanisms involving ACTR5 may contribute to neurodevelopmental disorders. Consequently ACTR5 provides a meaningful target in understanding pathological states linked to chromatin and gene regulation abnormalities.