Abcam, ab223036, Anti-IFT46 antibody

Size: 50µL
Rabbit Polyclonal IFT46 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IFT46.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human IFT46.Q9NQC8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IFT46 also known as Intraflagellar Transport 46 is a component of the intraflagellar transport (IFT) complex B. It plays a mechanical role in the assembly and maintenance of cilia and flagella by transporting cargo along the axonemal microtubules. IFT46 has a molecular mass of approximately 41 kDa. This protein is generally expressed in cells possessing cilia or flagella such as those in the respiratory tract and reproductive system.
Biological function summary
IFT46 interacts with other IFT complex B proteins to facilitate efficient transport within cilia and flagella. It acts as a linker that binds both the IFT-B complex and cargo ensuring proper docking and transport. IFT46 forms part of a complex that includes proteins like IFT52 and IFT88 which are integral for the regular functioning of ciliary transport.
Pathways
IFT46 participates in the intraflagellar transport pathway that is essential for cilia formation and maintenance. IFT46 operates in conjunction with proteins such as IFT52 and IFT81 which are also part of the IFT-B complex within this pathway. This pathway is important for the Hedgehog signaling pathway closely tied to developmental signaling and cellular homeostasis.
IFT46 mutations or malfunctions have been linked to ciliopathies such as Joubert syndrome and Bardet-Biedl syndrome. These disorders arise from defective ciliary function. In the context of Joubert syndrome IFT proteins like IFT88 and IFT172 may also be involved indicating shared molecular pathways and potential shared therapeutic targets.