Abcam, ab223041, Anti-IQCG antibody

Size: 50µL
Rabbit Polyclonal IQCG antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human IQCG aa 1-150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human IQCG aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q9H095

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IQ Domain-Containing G (IQCG) is a protein known for its role in intracellular signaling. It presents alternative names including IQ motif-containing protein G. Its molecular weight is approximately 75 kDa. IQCG expresses mainly in testicular tissue suggesting a specialized function in reproductive biology. The protein contains conserved IQ motifs which indicate its ability to bind calmodulin and potentially influence calcium signaling related activities.
Biological function summary
The processes involving IQCG impact regulation of spermatogenesis an important reproductive process. IQCG is part of a larger multi-protein complex that contributes to centrosome and cilium formation. By interacting with calmodulin it may modulate cellular responses to calcium fluctuations that are necessary for male germ cell division and differentiation.
Pathways
IQCG integrates into the cilium assembly pathway and the calcium signaling pathway. These integrative roles suggest IQCG may collaborate with proteins such as centrin and calmodulin facilitating the proper assembly and function of cilia. Such interactions are critical for cellular processes like movement and cell cycle regulation highlighting IQCG's function in specialized cellular contexts.
Altered IQCG function associates with male infertility and some ciliopathies. Male infertility might link to disturbed spermatogenesis due to improper centrosome or cilium assembly. Additionally proteins such as centrin along with IQCG suggest possible mechanistic pathways of pathology within the context of ciliopathies where altered cellular structures contribute to disease development.