Abcam, ab223768, Anti-LAP2 antibody

Size: 100µL
Rabbit Polyclonal LAP2B antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The LAP2 protein also known as Lamin-Associated Polypeptide 2 plays a significant role in the structural organization of the nuclear envelope. This protein exists in various isoforms with LAP2β being among the most studied. LAP2 has a molecular mass ranging from 45 to 80 kDa depending on its isoform. LAP2 shows expression in nuclear membrane and endoplasmic reticulum and these locations enable it to participate in the anchorage of chromatin and nuclear lamina to the inner nuclear membrane.
Biological function summary
The LAP2 protein acts as a scaffold for several nuclear processes. It interacts with lamin proteins forming complexes that are vital for both nuclear assembly and structural stability. Through these interactions LAP2 not only assists in maintaining nuclear shape but also plays a role in DNA replication and gene expression regulation. By facilitating interactions between chromatin and the inner nuclear membrane LAP2 influences the spatial organization of genetic material within the nucleus.
Pathways
The LAP2 protein engages in the regulation of key cellular processes such as the cell cycle and apoptosis. In the context of the cell cycle LAP2 associates with nuclear lamins and other nuclear envelope components impacting the dynamic disassembly and reassembly of the nuclear envelope during mitosis. In apoptosis pathways LAP2 interacts with proteins like BAF (Barrier-to-Autointegration Factor) affecting chromatin condensation and DNA fragmentation phases.
LAP2 protein alterations show connections to cardiac and muscular pathologies. Mutations or dysregulation of LAP2 protein can contribute to Emery-Dreifuss muscular dystrophy a condition often linked with mutant nuclear envelope proteins including emerin and lamins. Additionally LAP2 has relevance in dilated cardiomyopathy where its interaction with lamin A/C becomes impaired leading to improper nuclear structural integrity and function.