Abcam, ab223784, Anti-CCDC8 antibody

Size: 100µL
Rabbit Polyclonal CCDC8 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Coiled-coil domain-containing protein 8 aa 350-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Coiled-coil domain-containing protein 8 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q9H0W5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CCDC8 protein known as Coiled-Coil Domain Containing 8 has a molecular mass of approximately 64 kDa. This protein is primarily expressed in the brain and other tissues where it plays a part in various cellular functions. CCDC8 is involved in processes that require structural support reflecting its high presence in complex cellular environments. Alternate names for CCDC8 include 3M2 or C3orf10 which sometimes appear in research literature.
Biological function summary
CCDC8 interacts in the cell's cytoskeleton organization. This protein is part of the 3M complex which includes proteins such as CUL7 and OBSL1. The 3M complex is involved in maintaining cellular integrity and influencing cell cycle regulation. CCDC8 helps in achieving appropriate responses to cellular stress conditions ensuring proper cell function and survival.
Pathways
You can find CCDC8 active in the DNA damage response and cell cycle pathways. These pathways are critical for maintaining genomic stability and CCDC8 has related interactions with proteins like TP53 a well-known tumor suppressor. CCDC8 also interacts in growth regulatory pathways linking it with other influence sensors that control cell division and differentiation.
CCDC8 mutations relate to 3M syndrome a disorder characterized by growth retardation. This syndrome links CCDC8 with proteins CUL7 and OBSL1 highlighting their combined role in skeletal development. Additionally CCDC8 has associations with cancer as its interaction with TP53 influences tumor growth regulation. Understanding these links aids studies in genetic disorders and cancer development.