Abcam, ab224083, Anti-GLG1 antibody

Size: 100µL
Rabbit Polyclonal GLG1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GLG1 aa 950-1150.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GLG1 aa 950-1150. The exact immunogen used to generate this antibody is proprietary information.Q92896

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GLG1 also known as Golgi apparatus protein 1 or p58 is a transmembrane protein with a molecular weight of about 150 kDa. It expresses abundantly in the Golgi apparatus where it functions in the sorting and transport of proteins. GLG1 interacts with glycoproteins containing high mannose aiding their retention until they mature and are fully processed. Its expression is observed not only in most cell types but also prominently in tissues with high secretion activity.
Biological function summary
The function of GLG1 involves participating in the formation and maintenance of the Golgi structure. It is part of the larger protein complex responsible for trafficking glycoproteins within the cell. GLG1 collaborates with other proteins within the Golgi to ensure proper processing and modification of proteins by glycosylation. This involvement makes GLG1 critical in regulating protein quality control and maintaining organelle integrity within cells.
Pathways
The function of GLG1 integrates into the secretory and endoplasmic reticulum-to-Golgi transport pathways. The target aids in modulating protein folding and sorting processes that are essential for cellular homeostasis. It has functional interactions with other Golgi-related proteins like GM130 and proteins involved in transport such as COPI coated vesicle proteins. It plays a supporting role in vesicular trafficking ensuring that proteins reach their correct cellular destinations.
Dysfunctions or alterations in GLG1 expression are linked to congenital disorders of glycosylation. These disorders occur due to impaired glycoprotein processing and transport. GLG1's involvement in these pathways further implicates it in diseases where protein trafficking and glycosylation are disrupted. Moreover it is linked with diseases involving disrupted Golgi function which could be associated with proteins like GOLPH3 that might also have roles in Golgi-related pathologies.