Abcam, ab224105, Anti-RRP1B antibody

Size: 100µL
Rabbit Polyclonal RRP1B antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RRP1B aa 300-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RRP1B aa 300-500. The exact immunogen used to generate this antibody is proprietary information.Q14684

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RRP1B also known as Ribosomal RNA Processing 1B is a protein involved in the processing of pre-rRNA. It has a molecular mass of approximately 85 kDa. RRP1B is widely expressed in human tissues including high expression levels in the nucleus of cells. As its name implies RRP1B interacts with components involved in the maturation of rRNA and plays a role in the assembly and modification of the nucleolus.
Biological function summary
RRP1B engages in chromatin remodeling and modulates the expression of genes. It is part of a complex responsible for nucleolar rRNA processing. This protein is not only important for rRNA maturation but also influences the transcriptional regulation of several genes through chromatin reorganization. These activities highlight its involvement in both gene expression regulation and cellular structural organization.
Pathways
RRP1B significantly impacts cellular pathways related to ribosome biogenesis and chromatin modification. In the ribosome biogenesis pathway it collaborates with proteins such as NOP52 and NOP56 to ensure proper rRNA processing and ribosome assembly. Additionally RRP1B interacts within the chromatin-modifying pathway coordinating with proteins like CHD and SW1/SNF complexes to regulate gene expression.
RRP1B has links to cancers including breast cancer. Alterations in RRP1B expression or function can influence cancer progression as it may affect metastasis and chromatin organization. Researchers also study interactions between RRP1B and proteins such as BRCA1 which is involved in DNA repair processes to understand its potential impact on tumor development and progression.