Abcam, ab224113, Anti-LMO7 antibody

Size: 100µL
Rabbit Polyclonal LMO7 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human LMO7 aa 650-850.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LMO7 aa 650-850. The exact immunogen used to generate this antibody is proprietary information.Q8WWI1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LMO7 known also as LIM-only protein 7 plays a significant mechanical role in cellular architecture and gene expression. This protein with a molecular mass of approximately 165 kDa not only localizes to the nuclear envelope but also to the cytoplasm. It is found in many tissues with higher expression levels noted in skeletal muscle and heart tissue. LMO7 contains LIM domains that facilitate protein-protein interactions important for its varied functions within the cell.
Biological function summary
LMO7 supports cellular integrity and function through its roles at the nuclear periphery. It interacts with nuclear and cytoskeletal elements contributing to processes such as nuclear shaping and stability. LMO7 participates in the assembly of the mechanotransduction complex at the nuclear membrane. This role links external mechanical signals to gene expression regulation involving other proteins in the complex and helping cells respond to mechanical stress.
Pathways
This protein integrates into the mechanotransduction pathway and the actin cytoskeleton signaling. It interacts with cellular components such as emerin and nesprin impacting cytoskeletal dynamics and nuclear positioning. In doing so LMO7 influences signal transduction pathways that affect cell migration and structural maintenance which represent important physiological functions.
LMO7 associations appear in certain muscular dystrophies and cancer. Its interaction with proteins like emerin suggests implications in Emery-Dreifuss muscular dystrophy a condition characterized by weakened skeletal muscles. Additionally altered LMO7 expression or function has connections to certain cancers where it may affect tumor suppressor pathways and metastatic potential linking it indirectly to aberrations in cell adhesion and motility.