Abcam, ab224120, Anti-MYO10 antibody

Size: 100µL
Rabbit Polyclonal MYO10 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MYO10 aa 900-1050.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYO10 aa 900-1050. The exact immunogen used to generate this antibody is proprietary information.Q9HD67

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Mechanically MYO10 also known as Myosin-X is an unconventional myosin motor protein with a molecular mass of approximately 237 kDa. This protein has a significant presence in specialized cellular structures such as filopodia and neuron growth cones. It functions as a motor that transports cellular cargo along actin filaments playing an important role in cellular movement and organization. Expression of MYO10 occurs in various tissues but it is notably abundant in the brain and testis.
Biological function summary
MYO10 facilitates several cellular processes by mediating actin-based transport and cellular structure dynamics. It forms part of a complex network interacting with actin filaments influencing the dynamics of cell protrusions such as filopodia. These processes are essential for cell migration development and intracellular transport where MYO10 acts as an anchor enabling cells to respond to external stimuli and migrate accordingly.
Pathways
MYO10 interacts with various molecular networks influencing critical signaling cascades. It plays a significant role in the Wnt signaling pathway by interacting with Dishevelled (Dvl) proteins impacting cell polarization and movement. Additionally MYO10 is involved in integrin signaling facilitating the formation of adhesive contacts necessary for cell movement linking proteins such as talin and integrins into the pathway for integrative structural and signal modulation.
MYO10 has connections with certain pathologies particularly cancer and neurological disorders. Abnormal expression or mutation of MYO10 could contribute to cancer progression by disrupting normal cell migration and adhesion thereby aiding metastasis. In neurological disorders MYO10 has associations with proteins such as Reelin and its dysregulation could contribute to impaired neuronal migration or connectivity elucidating some neurological pathologies.