Abcam, ab224224, Anti-YIPF6 antibody

Size: 100µL
Rabbit Polyclonal YIPF6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human YIPF6 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human YIPF6 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q96EC8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
YIPF6 also known as YIP1 family member 6 is a protein involved in vesicular transport and membrane trafficking. It has a molecular mass of approximately 35 kDa. The protein localizes primarily at the Golgi apparatus and is expressed in various tissues particularly in those with high secretory functions such as the liver and pancreas. YIPF6 plays a significant role in maintaining Golgi structure and function by interacting with other Golgi-associated proteins.
Biological function summary
YIPF6 participates in the formation and maintenance of the Golgi complex. It functions as part of a larger protein complex collaborating with Rab Arf and other YIP family proteins to regulate vesicle budding and fusion. This activity is essential for proper protein and lipid trafficking within cells ensuring that the cellular export and import processes proceed efficiently. The protein's interactions with various co-factors highlight its role in sustaining intracellular logistics.
Pathways
YIPF6 is an essential component of the vesicular transport system and intracellular trafficking pathways. It closely associates with the COPI (coat protein complex I) pathway which mediates retrograde transport from the Golgi to the endoplasmic reticulum. YIPF6 also engages in related functions with proteins such as ARF1 a small GTPase critical for vesicle formation. These pathways highlight the protein's role in facilitating cellular transport mechanisms that are important for maintaining homeostasis within the cell.
YIPF6's dysfunction can link to conditions involving protein misfolding and trafficking defects such as certain neurodegenerative diseases. Mutations or alterations in YIPF6 may also relate to metabolic disorders where liver and pancreatic functions are compromised. Its connection with proteins like Rab GTPases and ARF1 emphasizes its involvement in the underlying pathophysiology of these diseases as these associated proteins play roles in the same trafficking pathways that could lead to cellular stress and impairment when disrupted.