Abcam, ab224323, Anti-Pinkbar antibody

Size: 100µL
Rabbit Polyclonal Pinkbar antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human BAIAP2L2 aa 350-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human BAIAP2L2 aa 350-500. The exact immunogen used to generate this antibody is proprietary information.Q6UXY1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as Pinkbar alternatively termed F-BAR domain containing 1 (F-BAR1) plays a mechanical role in membrane curvature modulation. Pinkbar is distinguished by its unique ability to form flat membrane protrusions unlike its BAR domain-containing relatives that create tubular structures. The protein has an approximate mass of 35 kDa and expresses widely with significant levels in intestinal epithelial cells. Its interaction with the actin cytoskeleton suggests a role in structural cell processes.
Biological function summary
Pinkbar influences the organization of the cell membrane and cytoskeletal dynamics. It integrates into membrane remodeling activities facilitating alterations in cell shape and motility. Pinkbar also participates as part of a larger protein complex that coordinates actin filament assembly. By binding to phospholipids and interacting with other cytoskeletal proteins Pinkbar conducts changes essential for cellular mechanical stability and communication.
Pathways
Pinkbar merges into cellular processes involving the actin cytoskeleton and the endocytosis pathway. The protein's performance in these pathways ensures efficient membrane-trafficking events and cell motility regulation. Pinkbar collaborates with proteins like actin and cortactin reinforcing the structural framework necessary for the upkeep of cellular architecture and endocytic functionality.
Pinkbar connects to conditions like intestinal inflammation and colorectal cancer. Its function in maintaining epithelial cell integrity underpins its role in disease; irregular activity can result in tissue damage or cancer progression. In intestinal inflammation Pinkbar interacts with proteins such as E-cadherin where disruptions in these interactions lead to compromised cell adhesion and increased disease susceptibility.