Abcam, ab224465, Anti-RGD1310794 antibody

Size: 100µL
Rabbit Polyclonal RGD1310794 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RBM48 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RBM48 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q5RL73

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RGD1310794 also known as Bcl-2-associated death promoter weighs around 23 kDa. This protein is expressed in various tissues throughout the body including the lymphatic tissues and the nervous system. Mechanically it promotes apoptosis by interacting with other proteins in the Bcl-2 family. Its expression increases in response to certain cellular stress signals aiding in the regulation of cell death processes.
Biological function summary
The protein plays a significant role in the apoptotic pathway as it is part of the pro-apoptotic complex. It enhances the release of cytochrome c from the mitochondria which is a critical step in apoptosis. When Bcl-2-associated death promoter forms complexes with Bax and Bak mitochondrial outer membrane permeabilization occurs. This function helps regulate cell populations and eliminates damaged or vulnerable cells.
Pathways
RGD1310794 is instrumental in the intrinsic apoptotic signaling pathway. It works closely with proteins such as Bax and Bak in mediating mitochondrial pathway activation. This pathway is essential for maintaining cellular homeostasis and is especially critical in tissue development and immune system balance.
Dysregulation of RGD1310794 activity is associated with cancer and neurodegenerative diseases. In cancer improper regulation of apoptosis can lead to uncontrolled cell growth making the apoptotic function of RGD1310794 highly relevant. In neurodegenerative conditions like Alzheimer's disease excessive apoptosis might contribute to neuronal loss. Proteins such as Bcl-2 which are known to oppose the action of RGD1310794 often play a role in the progression of these diseases.