Abcam, ab224516, Anti-TMEM205 antibody

Size: 100µL
Rabbit Polyclonal TMEM205 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human TMEM205 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TMEM205 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q6UW68

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TMEM205 also known as Transmembrane Protein 205 is an integral membrane protein involved in transportation processes across cellular membranes. It weighs approximately 26 kDa and primarily resides in the plasma membranes of cells. TMEM205 is expressed in a broad range of tissues with notable expression in the liver kidney lung and heart. This protein contributes to cellular processes by participating in the movement of various molecules across the cell envelope.
Biological function summary
It plays a role in cellular export mechanisms and likely intersects with the multidrug resistance (MDR) pathways. It does not form part of any larger protein complex but functions independently to modulate cellular response to different substances. Its presence associates with cellular export systems and impacts the ability of the cell to handle xenobiotics which are foreign chemical substances found within an organism.
Pathways
TMEM205 functions in the xenobiotic metabolism regulatory pathways and cellular stress response pathways. It interacts with proteins such as MDR1 (P-glycoprotein) and ABC transporters which are significant in drug resistance mechanisms. These interactions suggest its involvement in detoxification processes allowing cells to expel potentially harmful compounds and adapt to environmental changes.
TMEM205 has been connected to chemotherapy resistance in cancer notably influencing treatment outcomes. Its association with proteins like MDR1 contributes to this resistance by expelling chemotherapeutic agents from cells making treatment less effective. Additionally research indicates it may play a role in certain liver dysfunctions linking it to overall hepatic health and challenging the management of related disorders. Understanding TMEM205's function can aid in developing strategies to counteract drug resistance and support liver health.