Abcam, ab224613, Anti-GRAP2 antibody

Size: 50µL
Rabbit Polyclonal GRAP2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human GRAP2 aa 100-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WB, ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GRAP2 aa 100-300. The exact immunogen used to generate this antibody is proprietary information.O75791

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein GRAP2 also known as Gads plays an important role in intracellular signaling mechanisms. It is an adaptor protein with a mass of about 37 kDa. GRAP2 predominantly expresses in hematopoietic cells where it facilitates specific downstream signaling pathways. The protein assists in linking cell surface receptors to downstream signaling molecules enabling effective transmission of cellular signals.
Biological function summary
GRAP2 participates in the immune response by acting as a mediator that aids the assembly of signaling complexes. It often interacts with other proteins such as SLP-76 which is involved in specific immune cell activation. GRAP2 forms part of larger signaling complexes which are critical for the proper development and function of immune cells. This role highlights its importance in maintaining efficient immune surveillance and response.
Pathways
GRAP2 significantly contributes to the T-cell receptor (TCR) signaling pathway. It plays an integral part by interacting with proteins like LAT and ZAP-70 providing a scaffold for the further propagation of activation signals. Additionally in the Ras signaling pathway GRAP2 associates with other adaptor proteins coordinating downstream signaling needed for T cell activation and function.
GRAP2 has associations with immune system Pact conditions notably autoimmune diseases such as systemic lupus erythematosus (SLE). Its interactions with proteins like LAT and SLP-76 are important in these dysregulation of immune responses seen in these disorders. Any alteration in GRAP2 function or expression pathways could therefore potentially contribute to pathological immune activation reflecting its potential as a therapeutic target.