Abcam, ab224760, Anti-C1orf172 antibody

Size: 100µL
Rabbit Polyclonal C1orf172 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KDF1 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human KDF1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NAX2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
C1orf172 also known as chromosome 1 open reading frame 172 is a protein involved in various cellular processes. This target protein has a molecular mass of approximately 79 kDa. It is present in many tissues with higher expression noted in the brain and liver. The protein's structure and binding capabilities suggests it plays a role in cellular communication and intracellular signaling.
Biological function summary
C1orf172 participates in maintaining cellular homeostasis and possibly regulation of gene expression. Although not definitively proven to be part of a larger complex its interactions with other proteins suggest that it functions as a mediator in key biological processes. These roles are critical for maintaining normal cellular physiology and response to environmental changes.
Pathways
Involvement of C1orf172 in intracellular signaling pathways is evident specifically in the MAPK signaling pathway and the AMPK signaling pathway. C1orf172 interacts with proteins such as ERK and AMPKα within these pathways facilitating signal translation and energy homeostasis. These pathways are essential for cell growth metabolism regulation and adaptive responses.
Alterations in C1orf172 have been linked with neurological disorders and liver diseases. Particularly changes in expression or function of C1orf172 are associated with neurodegenerative diseases through its interactions with amyloid beta and tau proteins. Additionally the alterations in this protein could impact liver metabolism connecting it with hepatic conditions through its relationship with proteins like p53.