Abcam, ab225190, Alexa Fluor® 647 Anti-alpha 1a Adrenergic Receptor/ADRA1A antibody [EPR9691(B)]

Size: 100µL
Rabbit Recombinant Monoclonal alpha 1a Adrenergic Receptor/ADRA1A antibody - conjugated to Alexa Fluor® 647. Suitable for ICC/IF, Flow Cyt (Intra) and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR9691(B),
Isotype:IgG,
Conjugation:Alexa Fluor® 647,
Excitation/Emission:Ex: 650nm, Em: 665nm,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Concentration Range:0.5 mg/mL The concentration of this product may be batch-dependentBatch concentration finderBatch concentration finderEnter the lot number e.g. 'GR45436-1'SearchIf you need help,contact us

Product details:
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Stable for 12 months at -20°C, Store in the dark

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The alpha 1a Adrenergic Receptor also known as ADRA1A or alpha 1a receptor is a type of G protein-coupled receptor with an approximate mass of 56 kDa. It is a part of the adrenergic receptors family which are known for responding to adrenaline and noradrenaline. This receptor is expressed predominantly in smooth muscle tissues such as those in the prostate and blood vessels. Mechanically the A1 adrenergic receptor activates phospholipase C via Gq proteins leading to an increase in intracellular calcium levels.
Biological function summary
Alpha 1a Adrenergic Receptor plays a critical role in regulating smooth muscle contraction and blood vessel vasoconstriction. It forms an important part of the adrenergic receptor system which also includes alpha adrenergic receptors such as alpha 1b and alpha 1d subclasses. The activation of the alpha 1a receptor promotes vasoconstriction which contributes to blood pressure regulation. Additionally it is involved in modulating neurotransmitter release through its presence in nerve cells.
Pathways
Alpha 1a Adrenergic Receptor figures prominently in signaling pathways that manage cardiovascular functions. It is tightly associated with the GPCR signaling pathway which includes other adrenergic receptors and proteins like beta adrenergic receptors. Another significant pathway is the calcium signaling pathway where its impact on intracellular calcium plays a role in muscle contractions linking it to other proteins involved in the contraction machinery.
Alpha 1a Adrenergic Receptor connects to conditions such as hypertension and benign prostatic hyperplasia (BPH). The receptor’s role in vasoconstriction directly links to hypertension where it affects arterial blood pressure. In BPH the alpha 1a receptor influences prostate smooth muscle tone making it a target in treating urinary symptoms. These conditions involve proteins like angiotensin-converting enzyme in hypertension and other alpha receptors in BPH highlighting the ADRA1A's importance in therapeutic strategies.