Abcam, ab225714, Anti-LIMD1 antibody

Size: 100µL
Rabbit Polyclonal LIMD1 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LIMD1 aa 50-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LIMD1 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.Q9UGP4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LIMD1 also known as LIM domain-containing protein 1 is a protein with a molecular mass of approximately 76 kDa. It acts mechanically by functioning as a scaffolding protein important for assembling protein complexes at the cellular membrane. LIMD1 is expressed in many tissues with higher levels in lung and heart tissues. It contains LIM domains which enable protein-protein interactions necessary for proper cellular functions.
Biological function summary
LIM domain-containing protein 1 interacts with various proteins to regulate important cellular processes including cell proliferation and adhesion. It is part of the ubiquitin ligase complex and contributes to the regulation of gene expression by modulating transcriptional activity. Its function in gene silencing shows its role in maintaining normal cellular physiology and alterations can contribute to disease states.
Pathways
LIMD1 is involved in the Hippo signaling pathway and plays a role in cell contact inhibition and organ size control. It interacts with proteins like YAP (Yes-associated protein) to help control these processes. In addition LIMD1 contributes to the regulation of the p53 pathway inhibiting tumor progression by supporting p53-mediated cell cycle arrest and apoptosis.
LIMD1 plays important roles in cancer and respiratory diseases. Its interaction with p53 links it to tumor suppression where a loss or dysfunction of LIMD1 is often seen in cancers like lung cancer. Also its role in respiratory health associates it with COPD where alterations of LIMD1 may exacerbate disease progression. The relationship between LIMD1 and these diseases emphasizes its potential utility as a therapeutic target or biomarker.