Abcam, ab226294, Anti-ZCCHC6 antibody

Size: 100µL
Rabbit Polyclonal ZCCHC6 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TUT7 aa 800-850.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TUT7 aa 800-850. The exact immunogen used to generate this antibody is proprietary information.Q5VYS8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab226294 was affinity purified using an epitope specific to ZCCHC6 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZCCHC6 also known as Zinc finger CCHC-type containing 6 is a protein that binds RNA and has a mass of about 66 kDa. It belongs to the terminal uridylyl transferase (TUTases) family and functions by adding uridines to the 3' end of RNA substrates. This protein shows expression in multiple tissues including the brain testes and ovaries reflecting its potential involvement in diverse cellular processes.
Biological function summary
ZCCHC6 contributes to RNA metabolism influencing RNA stability translation and degradation. It participates in the post-transcriptional regulation of gene expression by adding uridines to mRNA and non-coding RNAs which can impact the decay and processing of these RNA molecules. ZCCHC6 is also part of a dynamic complex that includes components like poly(A) polymerases interacting with various cofactors to modulate RNA length and stability.
Pathways
The processes involving ZCCHC6 play significant roles in RNA processing pathways and in the regulation of gene expression. Its activity contributes to the RNA surveillance pathway which ensures the quality control of RNA transcripts. ZCCHC6 interacts with other key proteins such as ZCCHC11 which shares similar protein domains and functions in RNA uridylation reinforcing its cooperation in these pathways.
ZCCHC6 influences conditions linked to RNA dysregulation such as certain cancers and neurodegenerative diseases. The protein plays a role in maintaining RNA quality and abundance and disturbances in its function can lead to abnormal RNA profiles observed in these disorders. In cancer for example aberrant activity of ZCCHC6 might disrupt normal cell regulatory mechanisms potentially interacting with proteins like LIN28 to promote oncogenic processes.