Abcam, ab226338, Anti-UBAP1 antibody

Size: 100µL
Rabbit Polyclonal UBAP1 antibody. Suitable for IP and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human UBAP1 aa 1-100.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human UBAP1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.Q9NZ09

Product details:
This antibody is suitable for WB of IP pulldown but not suitable for WB of endogenous protein due to non-specific binding/high background.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab226338 was affinity purified using an epitope specific to UBAP1 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UBAP1 also known as Ubiquitin Associated Protein 1 functions in the endosomal sorting complex required for transport (ESCRT) pathway. It has a molecular mass of approximately 55 kDa. This protein binds ubiquitinated cargo as part of its role in sorting and trafficking cellular components for degradation. UBAP1 primarily expresses in the brain liver and lung tissues where it plays an important role in maintaining cellular homeostasis through the ESCRT-I complex.
Biological function summary
UBAP1 supports the regulation of protein degradation and recycling within the cell. As part of the ESCRT-I complex UBAP1 interacts with other ESCRT machinery to facilitate the formation of multivesicular bodies (MVBs). These MVBs transport ubiquitinated proteins to lysosomes for degradation. UBAP1 works closely with proteins such as TSG101 and VPS28 in this capacity ensuring efficient operational function of cellular waste management.
Pathways
Several cell processes rely on UBAP1's integration into the ESCRT system including vesicular trafficking and receptor degradation. Within the ubiquitin-proteasome system UBAP1 functions alongside proteins like VPS37B to regulate the sorting of ubiquitinated receptors into internal vesicles of the MVBs. Influencing the endosomal-lysosomal pathway UBAP1 ensures proper disposal of cellular components an important process for maintaining cell health.
UBAP1 mutations or dysfunctions have connections to neurodegenerative conditions and certain types of cancers. In particular its altered function has associations with frontotemporal dementia a disorder that affects brain functioning by impairing protein homeostasis. UBAP1 mutations link to ubiquilin 2 (UBQLN2) activity as both are involved in maintaining neural cellular health. Additionally a deficiency in UBAP1 function may contribute to the progression of hepatocellular carcinoma due to the disruption of normal degradation pathways and increased cellular stress.