Abcam, ab226396, Anti-PICOT antibody

Size: 100µL
Rabbit Polyclonal PICOT antibody. Suitable for IP, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human GLRX3 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human GLRX3 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O76003

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab226396 was affinity purified using an epitope specific to PICOT immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PICOT also known as thioredoxin-interacting protein (TXNIP) or Vitamin D3 up-regulated protein 1 (VDUP1) is a protein with a mass of approximately 39 kDa. It interacts with several cellular components including thioredoxin acting as a regulatory inhibitor. PICOT is expressed in a variety of tissues with notable presence in heart and muscle tissues. It influences the redox state of the cell playing a significant role in oxidative stress response.
Biological function summary
PICOT acts as a regulator of the thiol redox system in cells. It forms a complex with thioredoxin thereby inhibiting its activity which leads to an accumulation of oxidized proteins. This activity makes PICOT an important player in redox signaling affecting cellular responses to oxidative stress. Through its interactions PICOT contributes to cellular processes such as apoptosis differentiation and proliferation mediated by redox changes.
Pathways
PICOT is integral to the cellular oxidative stress response and redox regulation pathways. It interacts with proteins like thioredoxin and possibly influences NADPH oxidase activity. By modulating thioredoxin PICOT impacts the NF-kB signaling pathway which plays a role in inflammation and immune responses. These pathways highlight PICOT's involvement in maintaining cellular homeostasis especially in stress conditions.
PICOT has links to diabetes and cardiovascular disorders. It affects glucose metabolism and insulin signaling connecting to proteins such as insulin receptor substrates. PICOT also involves in heart disorders given its role in cardiac muscle stress responses and connection to proteins like troponin. Understanding these relationships can aid in developing therapeutic approaches for managing oxidative stress-related diseases.