Abcam, ab227110, Anti-Ym-1 + Ym-2 antibody [EPR15263] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal CHIL3 antibody. Carrier free. Suitable for ICC/IF, IHC-P, WB and reacts with Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15263,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab227110 is the carrier-free version of
ab192029
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Ym-1 and Ym-2 also known as chitinase-like proteins exhibit mechanical roles in the immune system without enzymatic chitinase activity. Ym-1 with a mass of approximately 43 kDa and Ym-2 are expressed predominantly in macrophages especially within inflammatory and allergic contexts. Expression is induced by IL-4 and IL-13 cytokines. Both proteins may also show presence in neutrophils and other innate immune cells during particular immune responses marking them important players in immune modulation.
Biological function summary
Ym-1 and Ym-2 regulate tissue repair and remodeling. They play an important role in cell proliferation and matrix formation which is actively involved in tissue homeostasis and wound healing. These proteins are not typically found as part of a larger complex but may interact with multiple signaling molecules in the cell's microenvironment. Their functions in shaping the extracellular matrix and facilitating cell migration make them significant in resolving inflammation.
Pathways
Ym-1 and Ym-2 are involved in the Th2 immune response and arginase pathways. They are associated with the regulation of Th2 cytokine production a pathway interconnected with adaptive immune responses to parasitic infections and allergic reactions. Ym proteins align with arginase pathways important in tissue repair and fibrosis and often correlate with Arginase-1 especially during inflammation and healing processes.
Ym-1 and Ym-2 connect predominately to asthma and fibrosis. Elevated levels observed in these conditions indicate their involvement in disease progression. In asthma Ym proteins modulate airway inflammation and remodeling collaborating with proteins like TGF-β to influence fibrosis and extracellular matrix deposition. The interaction between Ym proteins and such growth factors outlines their participation in pathological conditions offering potential targets for therapeutic interventions.